Bet-hedging and communication in E. coli

The E. coli lac operon has been shown to display bistability after induction with the gratuitous inducers IPTG and TMG. The project aims at elucidating whether lactose can also evoke bistable expression of the lac operon. Possible benefits of such an induction patters are going to be investigated. In addition, the effect of the important intracellular second messanger cAMP in bistable gene expression will be analysed and we want to investigate if extracellular cAMP represents a signal at the population level.


Contact details:
Dr. Katja Bettenbrock
MPI für Dynamik komplexer technischer Systeme
Experimentelle Systembiologie
Sandtorstrasse 1
D-39106 Magdeburg
Tel.: +49-(0)391 6110249
Fax: +49-(0)391 6110510
Homepage Link
Dr. Ilka Bischofs-Pfeifer
Universität Heidelberg
Bacterial Signaling Networks (BQ 0041)
BIOQUANT - room 602
Im Neuenheimer Feld 267
D-69120 Heidelberg
Tel.: +49-(0)6221 54 51 365
Fax.:+49-(0)6221 54 51 487
Homepage Link
Co-workers: Anja Marbach